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    Glossary of Key Terms

    Browse the definitions below to find explanations of many of the more technical terms you may come across on this site and in other resources on knee pain and treatment.

    AcetaminophenAcupuncture
    AnalgesicsArthralgia
    ArthritisArthroplasty
    ArthroscopeArthroscopy
    ArticularArticular Cartilage
    AsepticAspiration
    AvianBuffers
    CartilageChronic Synovial Inflammation
    CMSCo morbidities
    Contra lateralContraindicated
    Corticosteroid InjectionsCOX-2 Inhibitors
    Degenerative Arthritis/Degenerative Joint DiseaseEfficacy
    Elastoviscous/ElastoviscosityEndorphins
    GastrointestinalGlucocorticoids (steroids)
    HomeostasisHyaluronan/Hyaluronate
    Hyaluronic AcidImmunogenic
    Intraarticular InjectionsJoint Aspiration
    Joint FluidKnee Scope
    Magnetic Resonance Imaging (MRI)Molecular Weight
    Nonpharmacologic TherapyNSAIDs
    ORTHOVISC®Osteoarthritis
    OsteophytePhysiologic Saline
    PhysiotherapyPlacebo
    PreservativesPseudo septic reaction
    RheologicSpurs
    SubchondoralSynovial Fluid
    SynoviumTotal Joint Replacement
    ViscoelasticityViscosity
    Viscosupplementation Injections
    Acetaminophen

    A drug used to relieve pain and fever


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    Acupuncture

    Originally a Chinese practice of inserting fine needles through the skin at specific points especially to cure disease or relieve pain


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    Analgesics

    Agents for producing pain relief


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    Arthralgia

    Pain in one or more joints


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    Arthritis

    Inflammation of a joint or joints resulting in pain, swelling and stiffness


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    Arthroplasty

    The operative formation or restoration of a joint


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    Arthroscope

    An instrument for visualizing the interior of a hollow organ that is inserted through an incision near a joint (as the knee) and is used for the visual examination, diagnosis, and treatment of the interior of a joint


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    Arthroscopy

    Examination of a joint with a scope


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    Articular

    Of or relating to a joint


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    Articular Cartilage

    Cartilage that covers the articular surfaces of bones


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    Aseptic

    Freedom from infection, sterile


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    Aspiration

    The withdrawal of fluid from the body


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    Avian

    Derived from birds


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    Buffers

    A substance or mixture of substances that in a solution tends to stabilize and neutralize, within limits, both acids and bases


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    Cartilage

    A usually translucent somewhat elastic tissue that composes most of the skeleton


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    Chronic Synovial Inflammation

    Inflammation of synovial fluid lasting for a long period of time or marked by frequent recurrence


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    CMS

    Center for Medicare and Medicaid Services


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    Co morbidities

    Occurring or existing concurrently but unrelated pathological or disease process


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    Contra lateral

    Occurring on, affecting, or acting in conjunction with a part on the opposite side of the body


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    Contraindicated

    To make a treatment or procedure inadvisable


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    Corticosteroid Injections

    A steroid hormone produced by the adrenal cortex (the outer portion of the adrenal glands); administered as drugs they reduce swelling and decrease the body's immune response


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    COX-2 Inhibitors

    Any of a class of nonsteroidal anti-inflammatory drugs to relieve the pain and inflammation of arthritis and thought to minimize gastrointestinal side effects


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    Degenerative Arthritis/Degenerative Joint Disease

    Disease that leads to the gradual deterioration of a joint; also called Osteoarthritis.


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    Efficacy

    Capacity for producing a desired result or effect


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    Elastoviscous/Elastoviscosity

    And ideal viscosupplementation solution enhances elastic (high impact- such as running) and viscous (low impact- such as walking) properties in a knee with osteoarthritis


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    Endorphins

    Any of a group of endogenous peptides that bind chiefly to opiate receptors (in the cell membrane) and produce some of the same pharmacological effects (pain relief) as those of opiates (dulls the senses and induces relaxation)


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    Gastrointestinal

    Relating to or affecting both stomach and intestine


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    Glucocorticoids (steroids)

    Any of a group of steroid hormones, such as cortisone, that are produced by the adrenal cortex (the outer portion of the adrenal glands) and have anti-inflammatory properties


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    Homeostasis

    The maintenance of relatively stable internal physiological conditions such as body temperature or the pH of blood


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    Hyaluronan/Hyaluronate

    A substance found naturally in joint fluid that acts as a shock absorber and lubricant in the knee joint and is necessary for the joint to function properly.


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    Hyaluronic Acid

    A substance injected into a knee with osteoarthritis. Serves to restore lubrication and shock absorbing capabilities that have been depleted due to the disease of osteoarthritis.


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    Immunogenic

    Relating to or producing an immune response


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    Intraarticular Injections

    An injection administered by entering a joint


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    Joint Aspiration

    The act of removing a fluid from a joint in the body by a hollow needle connected with a suction syringe


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    Joint Fluid

    A transparent, lubricating fluid secreted by a membrane of an articulation (place of union between two or more joints) or bursa (a saclike body cavity between a tendon and bone)


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    Knee Scope

    Examination of a knee through an endoscope (an instrument for visualizing the interior of a hollow organ)


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    Magnetic Resonance Imaging (MRI)

    A special imaging technique used to image internal structures of the body particularly the soft tissues


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    Molecular Weight

    The sum of the atomic weights of all the atoms in a molecule


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    Nonpharmacologic Therapy

    A non-drug therapy, such as exercise, with therapeutic value


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    NSAIDs

    A nonsteroidal anti-inflammatory drug such as ibuprofen


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    ORTHOVISC®

    Ultra-pure natural hyaluronan that is injected intraarticular into the knee and is indicated in the treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics


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    Osteoarthritis

    Arthritis typically with onset during middle or old age that is characterized by degenerative (gradual deterioration of joint) and sometimes abnormal growth in the bone and cartilage of one or more joints and a progressive wearing down of opposing joint surfaces with consequent distortion of joint position and is marked symptomatically especially by pain, swelling, and stiffness; abbreviation (OA)


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    Osteophyte

    A bony outgrowth


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    Physiologic Saline

    An approximately 0.9 percent solution of sodium chloride; also called normal saline solution


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    Physiotherapy

    A therapy that uses physical agents such as exercise, massage and other modalities


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    Placebo

    An inert substance used especially in controlled experiments testing the efficacy of another substance such as a drug


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    Preservatives

    Something that preserves or has the power of preserving


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    Pseudo septic reaction

    Severe inflammation of the joint often with significant pain normally occurring 24 to 72 hours after intraarticular injection; often requires clinical intervention


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    Rheologic

    Of or relating to the phenomena of flowing matter


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    Spurs

    A sharp, bony outgrowth located at the end of a bone


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    Subchondoral

    Situated beneath cartilage


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    Synovial Fluid

    A lubricating fluid resembling the white of an egg, secreted by certain membranes, as those of the joints; also called joint fluid


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    Synovium

    The inner membrane of a joint capsule surrounding a freely movable joint.


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    Total Joint Replacement

    Repair of a damaged joint by replacing with a synthetic joint implant, made of either plastic, ceramic, titanium or stainless steel, in an effort to return normal function to affected joint


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    Viscoelasticity

    Having the quality of being thick and slow-flowing


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    Viscosity

    The property of resistance to flow in a fluid


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    Viscosupplementation Injections

    A procedure that replaces diseased synovial fluid in people with osteoarthritis of the knee in an effort to decrease pain, enhance range of motion and increase joint mobility


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